When Does "Alien: Romulus" (2024) Take Place?
"Alien: Romulus" is science fiction horror film written by Fede Álvarez with Rodo Sayagues that released August 16th, 2024. So when is "Romulus" set?
It takes place on the fictional Alien vs. Predator timeline in the year:
We know this because at one point a character uses a computer screen that reads: "ACTUAL TIME 9 FEB 2142 LOCATION ZETA2 RETICULI SYSTEM". So it is almost certainly February of 2142 AD.

2142 AD
We know this because at one point a character uses a computer screen that reads: "ACTUAL TIME 9 FEB 2142 LOCATION ZETA2 RETICULI SYSTEM". So it is almost certainly February of 2142 AD.
This StackExchange user's post examines its exact setting.
It is a midway chronological film in the Alien vs. Predator timeline (the chronological fifth film to feature an alien xenomorph) and can be watched either at its timeline point or entirely separately.
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